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The nature of the cellular infiltrate depends on the form of histiocytosis and on the duration of the existence of the lesion. In fresh foci, type 1 cells and eosinophils prevail, with the progression of the process, type 3 cells appear, and later type 4 cells are observed and the number of eosinophils is reduced.

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The localization and nature of the elements of the rash in Abt-Letterer-Siwe disease are very similar to the manifestations of seborrheic dermatitis, the diagnosis of which is usually made at the beginning. However, a closer examination reveals petechial elements, dotted scars at the site of former lichenoid papules, which is not observed in seborrheic dermatitis.

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The general condition of the child, the nature of buspirone pills to other organs and systems (polyadenopathy, destructive changes in bone tissue, lung damage, otitis media and mastoiditis, hepatosplenomegaly, laboratory data) also speak against seborrheic dermatitis. In case of difficulties in diagnosis, the data of histological examination of the elements of the rash and lymph nodes help.

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The appointment of glucocorticoids is pathogenetically justified, since they inhibit the function of the reticulohistiocytic system, stimulate hematopoiesis, normalize metabolism, etc.

Treatment of reticulohistiocytosis. They are prescribed for a long time - until the clinical signs of buspar disappear. The dose of the drug (in terms of prednisolone) should be from 1 to 2 mg per 1 kg of body weight per day. A gradual decrease in the dose of the drug continues for several months, and sometimes years, until a more or less prolonged remission. In cases of accession of intercurrent diseases (OVRI, chicken pox, measles, scarlet fever, etc.), as a rule, an exacerbation of the disease occurs, which dictates the need to increase the dose of glucocorticoid for this period and prescribe antibiotics for 3-4 weeks. Courses of antibiotics are periodically repeated.

In combination with glucocorticoids, a number of patients are prescribed cytostatic agents (6-mercaptopurine, leukeran, degranol, etc.) for health reasons. The use of anabolic drugs (dianobol, methylandrostenediol) should be carried out with some caution in order to avoid exacerbation of the pathological process (enlarged lymph nodes, tumor-like bone formations), as K. A. Moskacheva rightly warns about. Injections of gamma globulin, blood transfusions, as well as X-ray therapy on the foci of the affected bone tissue are shown. Assign ascorbic acid, B vitamins, especially calcium pantothenate.

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Prevention of Abt-Letterer-Siwe disease is reduced to the protection of a pregnant woman from various harmful exogenous influences. First of all, ionizing radiation and viral infections should be avoided, which can have an adverse effect on the fetus and contribute to the disruption of the regulatory mechanisms that control buspar and reproduction of reticulohistiocytic cells. The prognosis is unfavorable in case of damage to the visceral organs, the skeletal system and other tissues. With sometimes exclusively skin forms of the disease, complex therapy with the use of glucocorticoids leads to recovery. After the onset of clinical, hematological and radiological remission, due to the possibility of an exacerbation of the disease, especially with intercurrent diseases, children should be under constant dispensary observation.

 

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Abt-letterer-siwe disease. Letterer-Siwe-Abta disease.

There are many diseases that at first do not manifest themselves in our body, but in the end it turns out that, unfortunately, it is too late to treat them. Each disease has its own specific signs, characteristic external manifestations - the so-called symptoms of the disease.

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